Protective Effect of Curcumin Against Adverse Effects of Meloxicam in Rats

Document Type : Original Article

Authors

1 Department of Pharmacology, Faculty of Veterinary Medicine Benha University, Egypt

2 Dessouk Fever Hospital, Ministry of Health, Egypt

Abstract

The aim of the present study was to determine the adverse effects of meloxicam on lipid profile, glucose profile and
hematology as well as the protective effect of curcumin in rats. Thirty-six male Wister albino rats were randomly divided
into main four groups; Group (1): control (administered saline only 0.5 ml); Group (2): meloxicam was administered
intraperitoneally at level of 5.8 mg/kg body weight for 15 days; Group (3): curcumin extract was administered orally at
level of 200 mg/kg body weight for 15 days; Group (4): were administered meloxicam intraperitoneally with oral
administration of curcumin extract for 15 days. The findings revealed that there were significant increase in serum
cholesterol level and serum triglycerides level of rat given meloxicam. There were significant decrease in serum
cholesterol level and serum triglycerides of rats administered meloxicam with curcumin group. There was a significant
increase in serum glucose level of rat given meloxicam. There was significant decrease in serum glucose level of
meloxicam with curcumin group compared to meloxicam group. There was alteration in hematological parameters of rat
given meloxicam. On the contrary, there was an improvement in hematological tests of meloxicam with curcumin group
and improvement of histopathological study compared to meloxicam. On conclusion, administration of meloxicam
intraperitoneally 5.8 mg/kg body weight resulted in impairment in lipid profile, glucose profile and hematological
parameters and these impairments could be improved by curcumin administration.

Keywords

Benha Veterinary Medical Journal
Volume 33, Issue 2
December 2017
Pages 58-64

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