The present study was to evaluate anti-leukopenia and antioxidant effects of Moringa peregrina seeds oil at dose of 381 mg/kg in 400mg/kg.b.w Benzene and/or 20 mg/kg.b.w 5-Flourourasil induced leukopenia rats 2 weeks after induction of leukopenia in rats, Moringa peregrina seeds oil at dose of 381 mg/kg was administrated for 30 consecutive days. On the 31th day, the rats were sacrificed for the estimation of Hemoglobin (Hb%), Total Leucocyte Count (WBC) and Platelet Count (PLT) as well as biochemical parameters; Alanine Transaminase (ALT), Aspartate Transaminase (AST), Alkaline Phosphatase (ALP), Albumin(Alb) , Total Protein, Lactate Dehydrogenase (LDH), Creatine Kinase (C.K), Urea , Creatinine ,Reduced Glutathione (GSH), Superoxide Dismutase (SOD), Catalase (CAT), Total Cholesterol (T.Ch), Triglycerides (TG), P53 Gene Expression, Nitric Oxide (NO) , Thiobarbituric Acid Reactive Substances (TBARs) and Tumor Necroses Factor-α (TNF-α). The results of this study also showed that administration of Moringa peregrina seeds oil at dose of 381 mg/kg.b.w to leukopenia induced rats demonstrated a significant (P<0.01) increase in Hb%, WBCs and PLT as well as a significant (P<0.01) improvement in biochemical parameters and life span as compared to the benzene and /or 5-Flourourasil control rats. The histological examinations of this study revealed lung damage and degeneration in the lung of benzene and /or 5-Flourourasil treated rats. Also, lung of Moringa peregrina seeds oil at 381mg/kg rats showed significant improvement and protection against benzene and /or 5-Flourourasil harmful effect. On the other hand, the results clearly suggest that the oxidative stress of benzene higher than 5-Flourourasil
A., A., Abd El Mageed, A., Taha, W., & Hussein, M. (2015). Biochemical effect of Moringa peregrina Seeds on experimentally leukcytopenia in Rats. Benha Veterinary Medical Journal, 29(1), 151-163. doi: 10.21608/bvmj.2015.31813
MLA
Abdel-Maksoud H. A.; Afaf D. Abd El Mageed; Wafaa Abd El Zaher Taha; Mohammed A. Hussein. "Biochemical effect of Moringa peregrina Seeds on experimentally leukcytopenia in Rats". Benha Veterinary Medical Journal, 29, 1, 2015, 151-163. doi: 10.21608/bvmj.2015.31813
HARVARD
A., A., Abd El Mageed, A., Taha, W., Hussein, M. (2015). 'Biochemical effect of Moringa peregrina Seeds on experimentally leukcytopenia in Rats', Benha Veterinary Medical Journal, 29(1), pp. 151-163. doi: 10.21608/bvmj.2015.31813
VANCOUVER
A., A., Abd El Mageed, A., Taha, W., Hussein, M. Biochemical effect of Moringa peregrina Seeds on experimentally leukcytopenia in Rats. Benha Veterinary Medical Journal, 2015; 29(1): 151-163. doi: 10.21608/bvmj.2015.31813
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