@article { author = {amin, radwa and Abd Elaliem, Nabila and Abdeen, Ahmed and Ibrahim, Samar and Elsafty, Moamen and Beder, Ebtssam}, title = {Prospective Ameliorative Activity of Neem (Azadirachta Indica) on Iron Oxide Nanoparticle-Induced Multiple Organ Injury via Attenuating TNF-α Pathway}, journal = {Benha Veterinary Medical Journal}, volume = {44}, number = {1}, pages = {55-60}, year = {2023}, publisher = {Benha University; Faculty of Veterinary Medicine}, issn = {1110-6581}, eissn = {2974-4806}, doi = {10.21608/bvmj.2023.189946.1636}, abstract = {Neem trees (Azadirachta indica) have received a lot of academic interest recently because of their strong antioxidant and anti-proliferative capabilities. In this study, we evaluated the potential alleviating effect of neem on Fe2O3 NP -induced damage in brain, heart, and testis. Twenty-eight male albino rats were divided into four equal groups at random. The control group was given D.W orally for 45 days, Neem group was given 200 mg/kg/day orally for 45 days, Fe2O3 NP group was given 60 mg/kg of Fe2O3 NP I/P at the 31th-45th day, Fe2O3 NP +Neem group was given 200 mg/kg day of neem orally for 45 days + 60 mg/kg of Fe2O3 NP IP at the 31th–45th day. In the present investigation, histopathological examination of brain, heart, and testis sections revealed cellular degeneration and necrosis after Fe2O3 NP exposure. Also, TNF-α expressions were considerably elevated. Neem pr-treatment maintain tissue architecture in Fe2O3 NP-intoxicated rats. Our findings proved that neem have a potential protective impact against cellular damage induced by Fe2O3 NP through its anti-inflammatory, antiapoptotic, and antioxidant effects.}, keywords = {Fe2O3 NP,Neem,histopathology,Immunohistochemistry}, url = {https://bvmj.journals.ekb.eg/article_296319.html}, eprint = {https://bvmj.journals.ekb.eg/article_296319_657c7a5c0705a3fde729f85a72cd41b8.pdf} }