@article { author = {GabAllh, Mahmoud and El-mashad, AbdEl-baset and Amin, Aziza and Darweish, Marwa}, title = {Pathological studies on effects of ivermectin on male and female rabbits}, journal = {Benha Veterinary Medical Journal}, volume = {32}, number = {1}, pages = {104-112}, year = {2017}, publisher = {Benha University; Faculty of Veterinary Medicine}, issn = {1110-6581}, eissn = {2974-4806}, doi = {10.21608/bvmj.2017.31162}, abstract = {Ivermectin considered natural fermentation product derived from soil bacterium streptomyces avermitis and itis abroad spectrum insecticide, acaricide and anthelimintic. This studies carried out in order to investigate thehistopathological effects of therapeutic and double therapeutic dose of ivermectin on mature male rabbits aswell as effect of therapeutic dose of same drug on pregnant female rabbits. Forty mature rabbits were used inthis study (30 males and 10 pregnant female). Male rabbits received therapeutic and double therapeutic dosesof ivermectin, while female rabbits received therapeutic dose. The histopathological results revealed mild tomoderate reversible degenerative changes in examined organs of male rabbits received ivermectin weekly for4weeks meanwhile, this degeneration become more severe and extended to complete necrosis in some organsafter longer period and higher doses of ivermectin administration. As well as, pregnant females suffered fromabortion in some cases with fetal death. We concluded that ivermectin has adverse effect on male rabbits thatreceived either therapeutic or double therapeutic doses that varied from mild degenerative changes to completenecrosis of spermatogenic cells with complete absence of sperms. Meanwhile, female genital system wasseverely affected that showing severe degeneration and hemorrhage in uterus as well as atritic follicles anddegenerated ova in ovaries. So, caution must be considered for ivermectin administration especially duringbreeding season and for pregnant females.}, keywords = {Ivermectin,Pathology,Male rabbits,pregnant female rabbits}, url = {https://bvmj.journals.ekb.eg/article_31162.html}, eprint = {https://bvmj.journals.ekb.eg/article_31162_fece43fcb7398561c3fe9204335037fc.pdf} }