TY - JOUR ID - 240355 TI - Ameliorative effect of coenzyme Q10 against deltamethrin-induced renal toxicity in broiler chickens JO - Benha Veterinary Medical Journal JA - BVMJ LA - en SN - 1110-6581 AU - Aboubakr, Mohamed AU - Allam, Ali AU - said, alshaimaa AU - Ibrahim, samar AU - Youssef, Gehan AD - Department of pharmacology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt AD - Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt. AD - Biochemistry Department, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt AD - forensic medicine and toxicology, faculaty of veterinary medicine , benha university AD - Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt. Y1 - 2022 PY - 2022 VL - 42 IS - 1 SP - 17 EP - 24 KW - Deltamethrin KW - CoQ10 KW - Oxidative Stress KW - apoptosis KW - Broilers DO - 10.21608/bvmj.2022.117110.1499 N2 - The ameliorating effect of Coenzyme Q10 (CoQ10) supplementation was evaluated on broiler chickens intoxicated with deltamethrin (DM) through serum biochemical analysis, antioxidant capacity, and pathological examination. Cobb broiler chicks (60) aged 1 day were allocated into 4 experimental equal groups. For each group, three replicates of 5 chicks were used. The first group (control) received only the basal diet, the second group received CoQ10 (40 mg/kg diet), the third group received DM (300 mg/kg diet), and the fourth group received both DM (300 mg/kg diet) and CoQ10 (40 mg/kg diet). The experimental period was 35 days has been given to the last 3 groups. DM intoxication was associated with significant increases in creatinine, urea, malondialdehyde (MDA), and a drop in levels of reduced glutathione (GSH) and superoxide dismutase (SOD). In addition, DM increased blood cholesterol, triacylglycerols, and low-density lipoprotein (LDL), while lowered high-density lipoprotein (HDL). Caspase-3 and B cell lymphoma 2 (BCl2) were substantially unregulated by DM in the kidney tissues. The microscopic examination of the kidneys revealed congestion of the renal blood vessels with necrosis of the lining epithelium of the renal tubules. Concurrent supplementation of CoQ10 with DM resulted in a notable improvement in estimated parameters compared to the DM group. Dietary CoQ10 is therefore advised because of its preventive properties against DM-induced renal toxicity in broilers. UR - https://bvmj.journals.ekb.eg/article_240355.html L1 - https://bvmj.journals.ekb.eg/article_240355_ec46ad89fc27b1e9eafb0533d2f3c57d.pdf ER -