TY - JOUR ID - 296319 TI - Prospective Ameliorative Activity of Neem (Azadirachta Indica) on Iron Oxide Nanoparticle-Induced Multiple Organ Injury via Attenuating TNF-α Pathway JO - Benha Veterinary Medical Journal JA - BVMJ LA - en SN - 1110-6581 AU - amin, radwa Amin AU - Abd Elaliem, Nabila Mahmoud AU - Abdeen, Ahmed Abdel Hafez AU - Ibrahim, Samar Saber AU - Elsafty, Moamen Hussien AU - Beder, Ebtssam Gamal AD - Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Egypt. Menoufia University Hospital, Faculty of Veterinary Medicine, Sadat City University, Egypt. AD - Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Egypt. AD - Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Egypt. Y1 - 2023 PY - 2023 VL - 44 IS - 1 SP - 55 EP - 60 KW - Fe2O3 NP KW - Neem KW - histopathology KW - Immunohistochemistry DO - 10.21608/bvmj.2023.189946.1636 N2 - Neem trees (Azadirachta indica) have received a lot of academic interest recently because of their strong antioxidant and anti-proliferative capabilities. In this study, we evaluated the potential alleviating effect of neem on Fe2O3 NP -induced damage in brain, heart, and testis. Twenty-eight male albino rats were divided into four equal groups at random. The control group was given D.W orally for 45 days, Neem group was given 200 mg/kg/day orally for 45 days, Fe2O3 NP group was given 60 mg/kg of Fe2O3 NP I/P at the 31th-45th day, Fe2O3 NP +Neem group was given 200 mg/kg day of neem orally for 45 days + 60 mg/kg of Fe2O3 NP IP at the 31th–45th day. In the present investigation, histopathological examination of brain, heart, and testis sections revealed cellular degeneration and necrosis after Fe2O3 NP exposure. Also, TNF-α expressions were considerably elevated. Neem pr-treatment maintain tissue architecture in Fe2O3 NP-intoxicated rats. Our findings proved that neem have a potential protective impact against cellular damage induced by Fe2O3 NP through its anti-inflammatory, antiapoptotic, and antioxidant effects. UR - https://bvmj.journals.ekb.eg/article_296319.html L1 - https://bvmj.journals.ekb.eg/article_296319_657c7a5c0705a3fde729f85a72cd41b8.pdf ER -