TY - JOUR ID - 31274 TI - Concurrent use of ciprofloxacin and metronidazole for controlling of some bacterial infections in broiler chickens JO - Benha Veterinary Medical Journal JA - BVMJ LA - en SN - 1110-6581 AU - Abdel Ziz, Sayed A. AU - Abdel Motaal, Sabry M.A. AU - Abd-Allah, Osama E. AU - Sarhan, Marwa M.I. AD - Pharmacology Dept., Faculty of Vet. Med. Zagazig University AD - Animal Health Research Institute, Zagazig Branch Y1 - 2016 PY - 2016 VL - 31 IS - 2 SP - 83 EP - 92 KW - ciprofloxacin KW - Metronidazole KW - broiler KW - Clostridium KW - E. coli DO - 10.21608/bvmj.2016.31274 N2 - This study was carried out to investigate the efficacy of ciprofloxacin (8 mg/kg b.wt.) and/or metronidazole (30 mg/kg.b.wt.) in drinking water for 5 successive days for treatment of E. coli and/or Cl. perfringens each alone or both. Bloodand tissue samples were collected from 5 birds from each group on the 5th, 12th and 19th days post-infection and treatment.This was done through studying the effect on growth Performance (body weight, weight gain, feed consumption and feedconversion rate), lesion score, mortality rate, some liver and kidney function parameters and some blood pictureparameters. Infection with E. coli and/or Cl. perfringens induced the characteristic symptoms and lesions of the diseaseinfection with E. coli induced mortality rate up to 20% which is reduced to 5% post- treatment with ciprofloxacin whereas,Cl. perfringens infection induced mortality up to 35% which is reduced to 12% post-treatment with metronidazole. Mixedinfection with E. coli and Cl. perfringens induced 75% mortality which is reduced to 20% post-treatment with both drugs.Infection with E. coli and/or Cl. perfringens each alone or mixed together afforded a significant decrease in body weight,weight gain, feed consumption and increased feed conversion compared with normal control group. Whereas, treatmentof infected birds with both drugs elicited a significant increase in body weight, feed consumption and significant decreasein feed conversion rate compared with infected non-treated groups. On blood picture infection with E. coli and Cl.perfringens or their mixed infection induced a significant decrease in total RBCs count, Hb % and PCV% whereas,treatment of infected birds with each drug alone or their combination induced a significant increase in the previousparameters along the course of the study compared with infected non-treated groups. Serum Aspartate aminotransferase(AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), uric acid and creatinine were significantly elevatedin response to infection with each microbe alone or their combination compared with normal control group. Treatment ofinfected birds with each drug alone or their combination elicited a significant decrease in the previous parameters alongentire period of the study compared with the infected non-treated groups. Taken together, our data could be framed withinthe view of the revealing high efficacy of metronidazole and ciprofloxacin toward infection with clostridium and /or E.coli in poultry UR - https://bvmj.journals.ekb.eg/article_31274.html L1 - https://bvmj.journals.ekb.eg/article_31274_ea4fe5f9490df8e93aa3769552cf7c3d.pdf ER -