Document Type : Original Article
Authors
1
Department of biochemistry, Fac .of Vet. Med., Benha Univ., Egypt .
2
Department of Virology, Fac .of Vet. Med., Benha Univ., Egypt.
3
Department of Micro-biology and Chemistry, Fac .of Science, Benha Univ., Egypt .
Abstract
In the present study, the potential therapeutic effect of aqueous extract of psidium guajava leaves (GLE) on serum (Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Creatinine, Uric acid ,Lipase , Lactase , Na+/K+ ATPase and NF- KB) in mice suffering from diarrhea induced by bovine viral diarrhea virus (BVDV) infection was evaluated. Fourty –five male albino mice were divided into 3 equal groups (15 each). Group1 (normal control group), mice not infected with the virus and served as a control group. Group2 (diarrhea –induced group) ,mice infected with BVDV at adose of 0.25 ml once orally. Group 3 (P.guajava –treated group) ,Mice infected with BVDV at adose of 0.25 ml once orally and treated orally with 0.5 ml aqueous extract of P.guajava leaves at adose of ( 400 mg/kg b.wt /day) for 2 weeks . blood samples were collected from all groups after 2 weeks of treatment. The obtained results showed that, mice infected with BVDV had a significant increase in serum level of (glucose, creatinine, uric acid , NF-KB , ALT and AST) Meanwhile, ( Lipase, Lactase and Na+/K+ ATPase )activities were significantly decreased when compared to normal control group. Administration of diarrhea-induced group with aqueous extract of p.guajava (GLE ) significantly restored all biochemical parameters nearly to normal where serum levels of (glucose, creatinine, uric acid , NF-KB , ALT and AST) were significantly decreased Meanwhile, serum ( Lipase, Lactase and Na+/K+ ATPase) activities were significantly increased when compaered to diarrhea -induced group .
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