Protective effects of lycopene against Tilmicosin induced hepatic and pulmonary toxicity in male albino rats

Document Type : Original Article

Authors

1 General Organization of Veterinary Services. Department of Forensic Medicine and Toxicology. Fac. Vet. Med., Benha University

2 Department of Forensic Medicine and Toxicology. Fac. Vet. Med., Benha University

Abstract

The hereby study was designed to verify the deleterious effects of tilmicosin (TIL) on rats’ hepatic and lung tissues. Lycopene (LYC) is an antioxidant phytochemical carotenoid. Sixty male albino rats were used throughout the experiment. They were divided into six groups (No = 10), as follows: Group, 1  (control 1), injected subcutaneous (s/c) with isotonic saline solution, Group, 2 (control 2) administrated 0.2 ml olive oil oral by stomach tube daily and kept also as control and scarified after 15 days. Group, 3 ( LYC group) administrated 10 mg / kg of lycopene dissolved in olive oil and given by stomach tube daily and scarified after 15 days Group, 4 ( TIL group) administrated 60 mg / kg of tilmicosin single s/c dose and scarified after 5 days. Group, 5 (Prophylactic group) administrated 10 mg / kg of lycopene for 15 days, then 60 mg / kg tilmicosin s/c and scarified after 5 days. Group, 6 (Treatment group) administrated 60 mg / kg tilmicosin once s/c and administrated lycopene for 10 days then, the half of the group scarified after 5 days from lycopene administration and the other half after 10 days. LYC administration reduced the cytotoxic effects of tilmicosin on hepatic tissue, through improving the liver function biomarkers as alkaline phosphates (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and oxidant-antioxidant state. Increased ALP, ALT and AST activity may indicate that tilmicosin at the tested doses caused significant changes in hepatic tissues. Our findings reveal that LYC credited to have a noticeable protective effect against tilmicosin oxidative injury of the liver and lung tissue.   
 
 

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Benha Veterinary Medical Journal
Volume 36, Issue 1
March 2019
Pages 373-381

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