Effect of natural nanoparticles products on hepato-renal functions in breast carcinoma female rats

Document Type : Original Article


1 Clinical Biochemistry Department - Faculty of Veterinary Medicine-Benha University.

2 Phyto-chemistry Department-Medical and Aromatic Planets Department- Desert Research Center

3 Applied Chemistry Department - Egyptian Petroleum Research Institute

4 Phyto-chemistry Department-Medical and Aromatic Planets Department- Desert Research Center.


The aim of this study was to evaluate the effect of natural nano-composite products in combination with doxorubicin
chemotherapy treatment on serum biochemical profile in mammary cancer induced in fifty female rats divided as
following; control normal n= 10, mammary carcinogenesis Induced group with MNU (50 mg/ kg. b. wt. / I.P dose) n=40
which divided into three subgroups (10 rats in each group): mammary carcinoma non-treated gp, doxorubicin treated
group (33 mg /kg. b .wt. / I.P. dose), basic nano-curcumin (35 mg/ kg. b. wt. /oral dose) + doxorubicin treated group and
basic nano-brown algae (70 mg /kg. b .wt. / oral dose) + doxorubicin treated group. Blood urea nitrogen (BUN) and serum
creatinine level, AST and ALT activities were determined during the course of chemotherapy treatment among different
groups. The level of BUN, creatinine and AST activity were more than normal reference range in doxorubicin
chemotherapy treatment, basic nano-curcumin and basic nano-brown algae; while the value of serum ALT was reported
to be within the normal reference range in case of treatment by using basic nano-curcumin with doxorubicin
chemotherapy. In conclusion, the obtained results suggest that, treatment with chemotherapy and basic nano-curcumin in
combination improve serum biochemical profile in breast carcinoma induced in rats.