Comparative Study between the Use of Bulk and Nanoparticles of Zinc Oxide in Amelioration the Toxic Effects of Aflatoxins in rats

Document Type : Original Article


1 Regional Laboratory of Animal Health Research Institute, Agriculture Research Centre at Tanta, Egypt

2 Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Benha University, Egypt

3 Department of Mycology and Mycotoxins, Animal Health Research Institute, Agriculture Research Centre, Dokki, Cairo, Egypt


The ability of zinc oxide nanoparticles (ZnO-NPs) to ameliorate the toxic effect of aflatoxin B1
(AFB1) in rats in comparison with traditional bulk zinc oxide was evaluated in this study. Two
doses of bulk zinc oxide and ZnO-Nps (25 and 50 μg/kg body weight rat of each) were given orally
to rats experimentally treated with 50μg/kg b.wt rat AFB1 produced by aflatoxigenic Aspergillus
flavus strains. The experimental study extended for further 30 days. The obtainedresults revealed
that the low doses of zinc oxide nanoparticles were more effective than low or high doses of bulk
ZnO in amelioration the toxic effects of aflatoxicosis which reflected as enhancement in antioxidant
activity and histopathological picture of aflatoxicated rats.