Document Type : Original Article
Authors
1
1- El Menoufia University Hospital, Faculty of Medicine, El Menoufia University, Egypt. 2- Pharmacology department, Faculty of Pharmacy, Menoufia University, Egypt
2
Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt.
3
Deputy of AHRI for regional laboratories .AHRI.ARC.
4
DEPARTMENT OF PATHOLOGY, FACULTY OF MEDICINE, MENOFIA UNIVERSITY,EGYPT
Abstract
Cisplatin is one of the most frequently used drugs for cancer treatment. However, its uses was declined due to its dangerous side effect including nephrotoxicity. The aim of this study to examine the garlic and/or ginger ameliorative impact on cisplatin-caused nephrotoxicity in rats. Seven groups of rats (n=10) were used. Group I was administered 0.5 ml normal saline, group II was administered garlic (200 mg /kg), and Group III was administered ginger (310 mg/kg) orally once time per day for 21 consecutive days. Group IV was administered 0.5 ml normal saline orally once daily and injected cisplatin on 16th day [10 mg/kg, intraperitoneal (IP)].Group V was received garlic plus cisplatin, group VI was administered ginger plus cisplatin, and group VII was received garlic and ginger plus cisplatin. Twenty four hours following the last dose, the blood and tissue samples were collected for the biochemical, antioxidant, and histopathological examinations. Administration of cisplatin significantly increased serum urea level, creatinine level, and uric acid concentration. Furthermore, cisplatin significantly increased MDA level and induced a significant decrease in CAT, GSH, and SOD levels in renal tissue. Histologically, cisplatin induced marked degeneration of the renal tubular epithelium with lymphocytic cellular infiltration of the renal parenchyma. Treatment with ginger and/or garlic restores the levels of renal biochemical markers towards normalcy, improves oxidative stress and histological picture.
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