This study designed to evaluate the hepatoprotective effect of stem cells only or stem cells and levamisole on experimentally Carbon tetrachloride (CCl4) induced liver damage by evaluation of haematological parameters, biochemical parameters, immunological parameters and histopathological findings. Sixty (60) Wister rats were divided into four groups with 15 animals in each group. Group (1): normal group. Group (2): rats injected with CCL4 (0.2ml/100gm) s/c twice a week for 9 weeks. Group (3): rats injected with CCL4 then given MSCs (3x106 cell) I/v once a week for 4 weeks. Group (4): rats injected with CCL4 then given levamisole (2.5mg/kg) three successive days for 4 weeks and stem cells (MSCs) (3x106 cell) I/v once a week for 4 weeks. Results showed that injection of CCL4 lead to significant increase in activity of hepatic enzymes (AST, ALT, ALP) and Bilirubin level while it decreased serum total protein, albumin, IL- 6, Phagocytic index, Phagocytic %, IgG and IgM. While after treatment with stem cells only or stem cells and levamisole lead to significant decrease in activity of hepatic enzymes (AST, ALT, ALP) and Bilirubin level while it increased serum total protein, albumin, IL- 6, Phagocytic index, Phagocytic %, IgG and IgM
Fararh, K., Farid, A., Azzam, I., & Sultan, A. (2016). The hepato- protective Effect of Stem Cells and Levamisole against Carbontetrachloride induced Liver Fibrosis. Benha Veterinary Medical Journal, 31(2), 149-157. doi: 10.21608/bvmj.2016.31284
MLA
Khaled M. Fararh; Ayman Samir Farid; Ibtisam Mohammed Azzam; Asmaa Abdelmonsef Sultan. "The hepato- protective Effect of Stem Cells and Levamisole against Carbontetrachloride induced Liver Fibrosis". Benha Veterinary Medical Journal, 31, 2, 2016, 149-157. doi: 10.21608/bvmj.2016.31284
HARVARD
Fararh, K., Farid, A., Azzam, I., Sultan, A. (2016). 'The hepato- protective Effect of Stem Cells and Levamisole against Carbontetrachloride induced Liver Fibrosis', Benha Veterinary Medical Journal, 31(2), pp. 149-157. doi: 10.21608/bvmj.2016.31284
VANCOUVER
Fararh, K., Farid, A., Azzam, I., Sultan, A. The hepato- protective Effect of Stem Cells and Levamisole against Carbontetrachloride induced Liver Fibrosis. Benha Veterinary Medical Journal, 2016; 31(2): 149-157. doi: 10.21608/bvmj.2016.31284