Some adverse effects of cytarabine in leukemic rats

Document Type : Original Article

Authors

1 Department of pharmacology, Faculty of Veterinary Medicine, Benha University

2 Animal health research institute Benha branch

3 pharmaceutical company

Abstract

In the present work, the biochemical and hematological parameters as well as histological changes following intravenous
injection of 2 mg/ kg for 7 days and 3 mg cytarabine for 5 days in both normal and leukemic rats were studied. Sample
were taken in the first, second and third week after end of administration of cytarabine. Both normal and leukemic rats
showed significant increase in serum total bilirubin, AST, ALT, ALP, total protein and albumin after intravenous
administration of cytarabine either 2 mg/kg body weight for 7 days or 3 mg/kg body weight for 5 days. The effect of
intravenous injection of cytarabine either 2 mg/kg body weight for 7 days or 3 mg/kg body weight for 5 days on serum
creatinine level in normal and leukemic rats showed a significant changes of kidney function through estimation of serum
creatinine, urea and creatine kinase level. Intravenous injection of cytarabine either 2 mg/kg body weight for 7 days or 3
mg /kg body weight for 5 days induce significant increase on lipid profile (cholesterol and triglyceride) and MDA
concentration in normal and leukemic rats

Keywords

Benha Veterinary Medical Journal
Volume 31, Issue 2
December 2016
Pages 165-170

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