Some teratological effects of difloxacin in rats

Document Type : Original Article

Authors

Department of Pharmacology, Faculty of Veterinary Medicine, Benha University

Abstract

The aim of this experiment was to detect the teratogenic effects of difloxacin in Wister Albino rats.
Thirty pregnant rats were divided into 3 groups; group (1) behaved as control and received normal saline.
Group (2) was administered difloxacin at a dose of 20 mg/kg b. wt and group (3) was administered
difloxacin at a dose of 40 mg/kg b. wt orally once daily from 6th to 15th day of pregnancy. The study
revealed no teratogenic effect at a dose of 20 mg/kg b. wt, while at a dose of 40 mg/kg b.wt has
significant teratogenic effect showed by decrease in size, weight, length, retarded growth in fetuses, fetal
resorption of treated groups, the incidences of skeletal & visceral abnormalities were increased in treated
group (40 mg/kg b. wt). It could be concluded that. Administration of difloxacin during early stage of
pregnancy and at high dose induce some fetal abnormalities.

Keywords

Benha Veterinary Medical Journal
Volume 30, Issue 1
March 2016
Pages 266-271

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