Biochemical Study on antioxidant after High Effort

Document Type : Original Article

Authors

1 Department of Biochemistry, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Qalioubeya, Egypt

2 Biochemistry Department, Faculty of Pharmacy, October 6th University, October 6th city, Egypt

3 Department of Pharmacology, Faculty of Pharmacy, Misr University for Science and Technology (MUST), October 6th City, Egypt

Abstract

The present study was designed to evaluate hepatoprotective effects of Cranberry extract (75 and
150mg/kg.b.w) against Diclofenac sodium induced liver toxicity in rats. Oral administration of
Diclofenac sodium (150mg/kg.b.w.) led to significant increase in plasma Transaminases (L-Alanine and
L-Aspartate), Lactate dehydrogenase (LDH), Alkaline phosphatase (ALP), Tumor Nicroses Factor-Alfa
(TNF-α), Nitric oxide (NO) and TBARS as well as plasma, Triacylglycerol, Total Cholesterol, and LDLCholesterol.
Also, treatment of rats with Diclofenac sodium led to significant decrease in liver GSH,
Protein Thiols (Pr-SHs), Superoxide Dismutase (SOD), Catalase (CAT) as well as plasma HDL. The
obtained result revealed that cranberry extract (75 and 150mg/kg.b.w.) prevent liver tissue damage
through increasing of GSH, SOD and CAT activities and decrease significantly TBARs level. These
results suggest that, cranberry may be effective in enhances the protection of heart toxicity by its radical
scavenging effect and antioxidant activity

Keywords

Benha Veterinary Medical Journal
Volume 30, Issue 1
March 2016
Pages 358-367

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