Efficacy of canine parvovirus hyperimmune serum prepared in horses for treatment of canine parvo and feline panleucopenia infections

Document Type : Original Article

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Veterinary Serum and Vaccine Research Institute; Abassia, Cairo

Abstract

Anti-canine parvovirus hyper immune serum was successfully prepared in horses where it was found to
have specific canine parvovirus (CPV) neutralizing antibodies of a titer 1024/ml as determined by serum
neutralization test (SNT). Quality control testing of such serum revealed that it is free from bacterial,
fungal and mycoplasma contaminants as tested on specific media and safe as tested in puppies. Passive
immunization of CPV naturally and experimentally infected dogs and feline panleucopenia (FPL)
naturally infected cats with the prepared antiserum through inoculation of 2ml/ animal I/M for 5
successive days prevent the disease progress and mortality when administrated 2 days before infection
and up to 3 days post experimental infection. The protection decreased to 66% with delayed treatment
on the 4th day and become non protective at the 5th day post experimental infection. So it could be
concluded that specific anti-CPV hyper immune serum could aid to treat or even decrease the dangers
of CPV and FPL infection among dogs and cats when administered early to infected animals

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