Hepatoprotective effect of asparagus racemosus in paracetamol induced hepatotoxicity in rats

Document Type : Original Article

Authors

1 Department of Biochemistry, Fac. of Vet. Med., Benha Univ., Egypt

2 Department of Hygiene, Behavior and Management of animal, Fac. of Vet. Med., Benha Univ., Egypt

3 Department of Clinical Pathology, Fac. of Vet. Med., Benha Univ., Egypt

Abstract

The Asparagus racemosus was evaluated for its hepatoprotective activities against paracetamol induced
hepatotoxicity in rats. Forty rats were used divided into 2 groups, normal control: Composed from 10
rats and Hepatotoxicity induced group composed from 30 rats administrated of paracetamol by dose
1gm/kg b. wt. orally. For 10 days, then every 72h. Until the end of experiment time. This group
subdivided into 3 subgroup: 1-Paracetamol group: 10 rats as control negative. 2-Silymarin treated group:
10 rats taken silymarin by dose 100 mg/kg daily P.O. for (15) days (Kumar et al., 2011). 3-Asparagus
treated group: 10 rats administrated Asparagus racemosus powder by dose 500 mg/kg b. Wt. daily P.O.
for 15 days. (Kumar et al., 2011and Sara et al., 2013). Paracetamol-induced a significant increase in,
aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), with
marked reduction in superoxide dismutase (SOD) and catalase (CAT) activities. Treatment of rats with
Asparagus racemosus (500 mg/kg b. wt.) significantly altered serum marker enzymes and antioxidant
status to near a normal level against paracetamol-treated rats. Such hepatoprotective activities of
Asparagus racemosus were comparable to silymarin administrated (100 mg/kg b. wt. p.o.). The results
indicate that the hepatoprotective properties of Asparagus racemosus against paracetamol-induced
hepatotoxicity in rats

Keywords

Benha Veterinary Medical Journal
Volume 28, Issue 1
March 2015
Pages 133-137

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