Biochemical effect of some novel nanocompsite on metabolic changes in experimentally induced tumor in female mice

Document Type : Original Article

Authors

Department of Biochemistry, Faculty of Veterinary Medicine, Benha University

Abstract

Nanoparticles have one dimension that measures 100 nanometers or less. The properties of many
conventional materials will be changed when they are in nanoparticle form. This is typically because
nanoparticles have a greater surface area per weight than larger particles which make them to be more
reactive to other molecules. The aim of this study to demonstrate the biochemical effect of basic curcumin
– zinc oxide nanocompsite modified with vitamin C and surfactant induced experimentally in female mice.
This study was carried out on 80 mice and weighted 25-30 gm. Mice were classified into four groups Group
1: Non tumor bearing mice (act as normal control) .Group 2: Tumor bearing mice (act as tumor bearing
control group). Group 3: NTBM-treated with nanocompsite orally at dose of (1.850 g/kg /day) 6 weeks.
Group 4: TBM-treated with nanocompsite orally at dose of (1.850 g/kg /day) 6 weeks. Blood samples were
collected from all animals groups after 2, 4 and 6 weeks of treatment. Serum were separated and processed
directly for AST and ALT activities, Urea, Creatinine, Nitric oxide concentration and Interleukin-6 (IL-6)
and Interleukin-8 (IL-8) levels. The obtained results revealed that, these novel nanocompsite have a very
important role in improving liver and kidney functions and pro inflammatory agents

Keywords

Benha Veterinary Medical Journal
Volume 28, Issue 1
March 2015
Pages 138-149

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