Ameliorative effect of cinnamon and rosemary against acrylamide–induced renal injury in rats

Document Type : Original Article


1 Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt.

2 Department of Forensic Medicine Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt.


Acrylamide (ACR) is a contaminant found in heated food products. The exposure of humans and animals to ACR through their diet has become a serious issue. In response, natural dietary antioxidants have emerged as potential protective agents and health supplements to counteract the toxicity caused by dietary contaminants.

The study objective is to examine the side-effect of acrylamide on rats’ kidneys and investigate whether the use of cinnamon oil, rosemary oil, or a combination of both can reduce these negative effects while acrylamide is being induced. A total of 70 rats that were accustomed to the environment were randomly allocated into seven groups, each consisting of 10 rats, and were exposed to different treatments. These treatments were orally administered once daily for 28 consecutive days, then blood and kidney tissue samples were gathered.

The results of the study demonstrated that both rosemary and cinnamon offered some degree of protection to the kidneys. This was evidenced by the nearly normalized levels of parameters such as urea and creatinine. The observed nephroprotection provided by cinnamon and rosemary can be attributed to their ability to inhibit the oxidative stress induced by acrylamide. This was indicated by the reduction in renal lipid peroxidation product Malondialdehyde-(MDA) and the enhancement of antioxidative enzymes, specifically Glutathione-(GSH), and Catalase-(CAT), in the renal homogenate.

In conclusion, natural dietary antioxidants such as cinnamon and rosemary show promise in mitigating the adverse effects of acrylamide on the kidneys and could be explored further as potential therapeutic options for renal protection.


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