Biochemical Study of Anti-Inflammatory Effect of Osteoblastic Activator in Experimental Pancreatic Degeneration in Rat

Document Type : Original Article

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Department of Meat Biochemistry, Faculty of Veterinary Medicine, Benha University

Abstract

A total number of 160 Wister female rats, 12 -wk. old were , weighed and divided into five experimental groups to investigate the effect of streptozotocin (STZ) injection (30 and 60 mg/kg B.W) with and without zoledronic acid (0.15 mg/kg B.W) on some blood serum constituents such as  interleukins (IL-2, IL-6), immunoglobulin E (IgE) and cortisol. The results indicated that it's paralleled to the published data on the hyperglycemia and inflammatory condition in experimentally pancreatic degeneration. The current results showed that, injection with STZ was associated with a statistically significant elevation in serum IL-2, IL-6, IgE and cortisol but zoledronic treatment with STZ resulted in a decrease in serum IL-2, IL-6, IgE and cortisol. These results indicated that ZOL acid has beneficial effect to slow pancreatic carcinoma induction when treated with STZ at once in experimental animals

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Benha Veterinary Medical Journal
Volume 35, Issue 1
September 2018
Pages 164-170

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