Tannic acid nanoparticles improve the renal histological structure and kidney function in arsenic trioxide-induced renal damage

Gaber, Asmaa Mohamed; Moawed, Fatma; Abo-Zaid, Omayma

doi:10.21608/bvmj.2025.410464.1974

Tannic acid nanoparticles improve the renal histological structure and kidney function in arsenic trioxide-induced renal damage

Document Type : Original Article

Authors

¹ Biochemistry Department, Faculty of Veterinary Medicine, Benha University, Egypt.

² Health Radiation Research, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt.

10.21608/bvmj.2025.410464.1974

Abstract

There has been a lot of interest in antioxidant chemicals, especially those that come from natural sources like tannins and polyphenols. In this regard, nanomedicine has helped to uncover novel ways to administer and protect antioxidants. This study looked at the potential benefits and processes of polyphenol-based nanoparticles, particularly tannic acid nanoparticles (TANPs), on oxidative stress brought on by arsenic trioxide (ASO), which has been connected to kidney injury in rats. Over the course of 30 days, rats were given intraperitoneal injections of TANPs and ASO (4 mg/kg body weight daily). Light microscopy was used to evaluate changes in renal morphology. Serum urea and creatinine concentrations were measured. The findings showed that exposure to ASO had a significant impact on these serum nephritic markers. On the other hand, these changes were lessened by TANP pretreatment. A histological evaluation also validated the biochemical results. Overall, the findings suggested that TANPs' ability to prevent ASO-induced nephrotoxicity may be related to their ability to lower ROS-mediated apoptosis. These findings may aid in the creation of novel treatment strategies aimed at stopping the progression of renal cell injury.

Keywords