Calories restriction modulates the enzymatic antioxidant status in D-galactose induced aging in male rats

Document Type : Original Article

Authors

1 biochemistry department faculty of veterinary Banha university

2 Biochemistry veterinary medicine Banha university

3 Health radiation research, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt

4 atomic energy authority

Abstract

In postindustrial and modern societies, overeating and high calories consumption has emerged as new challenge in community health. Large effort is now being devoted to detect and evaluate the pathophysiologic consequences of aging and aging accompanying diseases. Several lines of evidence propose that caloric intake influences the speed of aging and the onset of linked diseases in animals and, possibly, humans. These are the clues of decreasing calories intake in this study to evaluate the effect on aging and to detect weather there are ways to control it. Thirty adult male albino rats were used in this work. ten rats as the control group, D-galactose was injected intraperitoneally to induce aging, then rats were sub divided into equal two groups, one group subjected to calories reduction while-the-other-took-normal-diet-.Catalase,-glutathione-and-MDA-were carried out to test the oxidative effect of D-galactose and possible protective effect of treatments. D-galactose induced impaired oxidative functions. Calories reduction improved D-galactose induced deterioration to a great extent as evidenced biochemically.

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