Evaluation of Inosine-Acedoben-Dimepranol as an immunomodulator in broiler chicks vaccinated with infectious bronchitis virus vaccine.

Document Type : Original Article


1 Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, EGYPT.

2 Virology department, faculty of vet medicine, Benha university.

3 Virology Department, Faculty of Veterinary Medicine, Benha University, Moshtohour, Kalubeya

4 Professor & Head, Department of Pharmacology, Benha University Faculty of Vet Medicine, 13736 Egypt.


Protecting livestock against diseases by enhancing its immunity is essential and required in poultry industry. Therefore, the aim of the present study was to evaluate the possible immunoenhancing effects of Inosine-Acedoben-Dimepranol (IAD) in broiler chicks. A total of 150 chicks were used in the present study, divided into 6 groups (25 for each) and subjected to different treatments. It has been found that IAD significantly (P≤ 0.05) increased total leukocytic count, with increased granulocyte (neutrophils, eosinophils, basophils), lymphocyte and monocyte counts compared to control chicks. IAD significantly (P≤ 0.05) increased total protein as a result of increased globulins in plasma when compared with those of control. IAD has been found to significantly (P≤ 0.05) increase immune response of IB vaccine in IAD+ IB vaccine-treated groups compared to control measured by ELISA. IAD exhibited antiviral effect indicated by increased survival percent of chicks challenged with virulent IB virus with survival 100% in the groups received IAD large dose plus vaccine.
Data of the present study may indicate that supplying chicks with IAD in drinking water is a good recommendation in poultry industry based on its immune enhancing properties.


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