Document Type : Original Article
Authors
1
Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt.
2
Histology Dept., Faculty of Veterinary Medicine, Benha University
3
forensic medicine and toxicology, faculaty of veterinary medicine , benha university
4
Department of pharmacology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt
Abstract
The purpose of this study was to see if N-acetylcysteine (NAC) and/or Vitamin E (Vit E) could help rats with renal damage caused by acrylamide (ACR). The antioxidant and nephroprotective efficacy of NAC and Vit E against ACR-induced nephrotoxicity in rats was investigated in this workThe rats were assigned to seven groups (each with seven rats): control vehicle group (saline only), NAC group (150 mg/kg, orally), Vit E group (100 mg/kg, orally), ACR group (20 mg/kg, orally), NAC+ACR group, Vit E+ACR group, and NAC+Vit E+ACR group. Creatinine, urea, and glucose concentrations in the blood rose as a result of ACR. Furthermore, ACR reduced protein and albumin levels. Malondialdehyde levels in kidney tissues increased dramatically as reduced glutathione, superoxide dismutase, and catalase levels decreased. ACR also caused certain degenerative lesions in the kidney tissues and elevated caspase-3 expression. NAC and Vit E, either alone or in combination reduced kidney toxicity and apoptosis caused by ACR.
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