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Benha Veterinary Medical Journal
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Abdel Ziz, S., Abdel Motaal, S., Abd-Allah, O., Sarhan, M. (2016). Concurrent use of ciprofloxacin and metronidazole for controlling of some bacterial infections in broiler chickens. Benha Veterinary Medical Journal, 31(2), 83-92. doi: 10.21608/bvmj.2016.31274
Sayed A. Abdel Ziz; Sabry M.A. Abdel Motaal; Osama E. Abd-Allah; Marwa M.I. Sarhan. "Concurrent use of ciprofloxacin and metronidazole for controlling of some bacterial infections in broiler chickens". Benha Veterinary Medical Journal, 31, 2, 2016, 83-92. doi: 10.21608/bvmj.2016.31274
Abdel Ziz, S., Abdel Motaal, S., Abd-Allah, O., Sarhan, M. (2016). 'Concurrent use of ciprofloxacin and metronidazole for controlling of some bacterial infections in broiler chickens', Benha Veterinary Medical Journal, 31(2), pp. 83-92. doi: 10.21608/bvmj.2016.31274
Abdel Ziz, S., Abdel Motaal, S., Abd-Allah, O., Sarhan, M. Concurrent use of ciprofloxacin and metronidazole for controlling of some bacterial infections in broiler chickens. Benha Veterinary Medical Journal, 2016; 31(2): 83-92. doi: 10.21608/bvmj.2016.31274

Concurrent use of ciprofloxacin and metronidazole for controlling of some bacterial infections in broiler chickens

Article 11, Volume 31, Issue 2, December 2016, Page 83-92  XML PDF (347.45 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2016.31274
Authors
Sayed A. Abdel Ziz1; Sabry M.A. Abdel Motaal1; Osama E. Abd-Allah2; Marwa M.I. Sarhan2
1Pharmacology Dept., Faculty of Vet. Med. Zagazig University
2Animal Health Research Institute, Zagazig Branch
Abstract
This study was carried out to investigate the efficacy of ciprofloxacin (8 mg/kg b.wt.) and/or metronidazole (30 mg/kg.
b.wt.) in drinking water for 5 successive days for treatment of E. coli and/or Cl. perfringens each alone or both. Blood
and tissue samples were collected from 5 birds from each group on the 5th, 12th and 19th days post-infection and treatment.
This was done through studying the effect on growth Performance (body weight, weight gain, feed consumption and feed
conversion rate), lesion score, mortality rate, some liver and kidney function parameters and some blood picture
parameters. Infection with E. coli and/or Cl. perfringens induced the characteristic symptoms and lesions of the disease
infection with E. coli induced mortality rate up to 20% which is reduced to 5% post- treatment with ciprofloxacin whereas,
Cl. perfringens infection induced mortality up to 35% which is reduced to 12% post-treatment with metronidazole. Mixed
infection with E. coli and Cl. perfringens induced 75% mortality which is reduced to 20% post-treatment with both drugs.
Infection with E. coli and/or Cl. perfringens each alone or mixed together afforded a significant decrease in body weight,
weight gain, feed consumption and increased feed conversion compared with normal control group. Whereas, treatment
of infected birds with both drugs elicited a significant increase in body weight, feed consumption and significant decrease
in feed conversion rate compared with infected non-treated groups. On blood picture infection with E. coli and Cl.
perfringens or their mixed infection induced a significant decrease in total RBCs count, Hb % and PCV% whereas,
treatment of infected birds with each drug alone or their combination induced a significant increase in the previous
parameters along the course of the study compared with infected non-treated groups. Serum Aspartate aminotransferase
(AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), uric acid and creatinine were significantly elevated
in response to infection with each microbe alone or their combination compared with normal control group. Treatment of
infected birds with each drug alone or their combination elicited a significant decrease in the previous parameters along
entire period of the study compared with the infected non-treated groups. Taken together, our data could be framed within
the view of the revealing high efficacy of metronidazole and ciprofloxacin toward infection with clostridium and /or E.
coli in poultry
Keywords
ciprofloxacin; Metronidazole; broiler; Clostridium; E. coli
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