Biochemical changes in carbohydrates metabolism in experimentally induced rheumatoid arthritis in rats

Abd Elhamid, Omnia M.; Fararh, Khaled Mohamed; Abdel Ghany, Mona Nawar

doi:10.21608/bvmj.2015.31680

Biochemical changes in carbohydrates metabolism in experimentally induced rheumatoid arthritis in rats

Document Type : Original Article

Authors

¹ Biochemistry Department, Faculty of Vet. Med. Benha University, Egypt

² Clinical Pathology Department, Faculty of Vet. Med., Benha University, Egypt

³ Biochemistry Department, Faculty of science, Al-Azhar University, Egypt.

10.21608/bvmj.2015.31680

Abstract

In the present study, the effect of Complete Freund`s adjuvant - induced rheumatoid arthritis on serum
Glucose, Nitric Oxide, Cortisol, Lactic acid, Pyruvic acid, Pantothenic acid, Pentosidine, Na/K ATPase,
Interleukin 8 and Sialic acid in rats have been evaluated. Forty female albino rats were divided into two
equal groups (20 each). Group Ι (Control group): received no drugs. Group II: (Rheumatoid Arthritis
group) injected subcutaneously with Complete Freund`s adjuvant at a dose of (0.1 mg /kg body weight
dissolved in 1 ml saline) for rheumatoid arthritis induction. Blood samples were collected from all
groups after 2 and 4 weeks from injection. The obtained results showed that there is the experimental
arthritis accompanied with significant increases in serum Glucose, Nitric oxide, Cortisol, Lactic acid,
Pentosidine, Interleukin 8 and Sialic acid levels. On the other hands, pyruvic acid level, Na/k ATPase
activity and pantothenic acid levels were significantly decreased

Keywords