Renal protective effect of cardamom against nephrotoxicity induced by gentamicin in rats

Elkomy, Ashraf; Aboubakr, Mohamed; Elsawaf, Noha

doi:10.21608/bvmj.2015.31681

Renal protective effect of cardamom against nephrotoxicity induced by gentamicin in rats

Document Type : Original Article

Authors

¹ Department of pharmacology, Faculty of Veterinary Medicine, Benha University, Egypt

² Department of pharmacology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt

10.21608/bvmj.2015.31681

Abstract

This study was conducted to evaluate the renal protective effect of cardamom against experimentallyinduced
gentamicin toxicity in rats. Forty adult male Westar albino rats were randomly grouped into
four groups (each of 10 rats). Rats in group (1) were orally administered saline (the vehicle) daily for 8
consecutive days and severed as control group. Group 2: were given gentamicin (80 mg/kg. b.wt. i.p.)
daily for 8 consecutive days. Group 3: were given gentamicin (80 mg/kg. b.wt. i.p.) daily for 8
consecutive days, then cardamom extract (100 mg/kg. b.wt. p.o.) daily from 9^th to 21^th days. Group 4:
were given gentamicin (80 mg/kg. b.wt. i.p.) daily for 8 consecutive days, then cardamom extract (200
mg/kg. b.wt. p.o.) daily from 9^th to 21^th days. Gentamicin-treated rats showed significant renal damage
as it increases creatinine, urea, glucose and total protein showed a significant decrease. While In groups
(gentamicin + cardamom 100 mg/kg & gentamicin + cardamom 200 mg/kg), showed significant
protection to rats kidney from structural and functional changes associated with gentamicin. Gentamicin
which induced nephrotoxicity can be prevented by co-administration with cardamom

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