Biochemical Effect of Experimental Hepatic Failure in Tissues Antioxidants in Aging Rats

Document Type : Original Article

Authors

1 Biochemistry Dep. Fac. of Vet. Med. Benha University

2 Animal Husbandry Dep. Fac. of Vet. Med. Damnhour University

3 Biochemistry Dep. Fac. of Vet. Med. Damnhour University

Abstract

The present study aimed to trigger the effect of experimentally induced chronic hepatic failure on tissues
antioxidant status in different ages the hepatic failure induced by Intraperitoneal administration of
Thioacetamide at a dose of (30 - mg/kg body weight) four times through two months with 15 days
interval Rats were sacrificed 24 hrs after the last dose of TAA the recorded data revealed significant
decrease in Brain tissue Monoaminooxidase (MAO) and significant increase in brain tissue nitric oxide
(NO) and ammonia, significant decrease in Brain, kidney, muscles and hepatic tissues Reduced
Glutathione (GSH) Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPX) from the recorded
results it could be concluded that hepatic failure is a hazard stress in tissues antioxidants in different
ages

Keywords

Benha Veterinary Medical Journal
Volume 29, Issue 2
December 2015
Pages 161-169

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