Evaluation of Antiproliferative activity of Taxol, Proanthocyanidin and Atorvastatin against human hepatocellular carcinoma cell line (HepG2).

Document Type : Original Article


1 Biochemistry Department, Faculty of Veterinary Medicine, Moshtohor, Banha University.

2 Department of Zoology, Research Laboratory of Molecular Carcinogenesis, Faculty of Science, Tanta University, Tanta 31527, Egypt


The sixth most frequent cancer in the world, with a significant morbidity and fatality rate, is liver cancer. Finding a suitable therapeutic alternative for these diseases is of utmost importance because various types of cancer annually result in thousands of fatalities worldwide. This study looks into Atorvastatin's anticancer effect is a competitive inhibitor of hydroxy methylglutaryl CoA reductase, which plays a role in anticancer activities in a range of malignancies, including human liver cancer. Proanthocynadine is a condensed tannin that has a variety of pharmacological effects. Because of their human health advantages and chemotherapeutic properties, these phytochemicals are classified as "offence and defence molecules." Taxol, an antimicrotubule chemotherapeutic medication, has been shown to be effective in the treatment of numerous HepG2 cancers (human liver carcinoma cell line). In this study, the effects of Atorvastatin, Proanthocynadine and chemotherapeutic Taxol on apoptosis was investigated by DNA fragmentation analysis. cell survival and apoptosis in liver cancer cell lines were analyzed using MTT assay. The results showed that Taxol, Atorvastatin and Proanthcyanidine inhibited the viability of HepG2 cells in a time- and dose-dependent manner, induced a significant enhancement of treated groups compared to untreated cells.


Main Subjects