The aim of this study was to evaluate the role of L-carnitine in the treatment of experimentally induced hypomagnesemia in sheep. This study was carried out on 10 ossimi rams aged 10-12 months old with an average live weight of 35±1.1 kg that were used for experimental induction of hypomagnesemia. Rams with induced hypomagnesaemia were divided into two groups according to the line of treatment. The first group (n=5) was treated by the traditional treatment alone while the second group (n=5) was treated by the traditional treatment in addition to L-carnitine (20 mg/kg I/V). The symptoms of hypomagnesemia appeared gradually until complete appearance of symptoms at day 28 post induction. There was significant decrease (P < 0.05) in serum magnesium (Mg), calcium (Ca), glucose and parathyroid hormone (PTH) in experimentally induced hypomagnesemic rams. However, there were significant increase (P < 0.05) in serum sodium (Na), potassium (K), urea, creatinine, cortisol, creatine phosphokinase (CPK) and troponin I (cTnI) in experimentally induced hypomagnesemic rams. Treatment of hypomagnesemia with traditional treatment and L-carnitine resulted in significant elevation (P < 0.05) of serum Mg, Ca, glucose and PTH in hypomagnesemic rams than traditional treatment only. However, there were significant reduction (P < 0.05) in serum K, urea, CPK and cTnI than traditional treatment only at 24 hour after treatment. Based on the results of this study we concluded that the addition of L-carnitine to the traditional treatment of hypomagnesaemia in sheep is effective and produced earlier and more pronounced recovery.
A. Y. Helal, M., Hefnawy, A., Y. Abokora, S., & S. Koptan, A. (2018). Evaluation of L-carnitine in the treatment of experimentally induced hypomagnesemia in sheep. Benha Veterinary Medical Journal, 35(2), 31-43. doi: 10.21608/bvmj.2018.48553
MLA
Mahmoud A. Y. Helal; Abdel-Ghany Hefnawy; Seham Y. Abokora; Ahmed S. Koptan. "Evaluation of L-carnitine in the treatment of experimentally induced hypomagnesemia in sheep", Benha Veterinary Medical Journal, 35, 2, 2018, 31-43. doi: 10.21608/bvmj.2018.48553
HARVARD
A. Y. Helal, M., Hefnawy, A., Y. Abokora, S., S. Koptan, A. (2018). 'Evaluation of L-carnitine in the treatment of experimentally induced hypomagnesemia in sheep', Benha Veterinary Medical Journal, 35(2), pp. 31-43. doi: 10.21608/bvmj.2018.48553
VANCOUVER
A. Y. Helal, M., Hefnawy, A., Y. Abokora, S., S. Koptan, A. Evaluation of L-carnitine in the treatment of experimentally induced hypomagnesemia in sheep. Benha Veterinary Medical Journal, 2018; 35(2): 31-43. doi: 10.21608/bvmj.2018.48553
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