Teratogenic Effect of Meloxicam on Pregnant Rats: Implication of Organogenesis Period

Elkomy, A.A; Abo Salem, Mohammed. S.; Kandeil, Asmaa M.; Hassan, A.; Elhemiely, A.A

doi:10.21608/bvmj.2018.96315

Teratogenic Effect of Meloxicam on Pregnant Rats: Implication of Organogenesis Period

Document Type : Original Article

Authors

¹ Pharmacology Department , Faculty of Veterinary Medicine Banha University, Egypt

² Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine Banha University, Egypt

³ National Organization for Drug Control and Research (NODCAR), Egypt

10.21608/bvmj.2018.96315

Abstract

This study was carried out to detect the risk of meloxicam use on fetuses. It was given to pregnant rats orally by dose1.35 and 2.70 mg/kg b.wt, from 6^th day until the 15^thday of gestation daily. At 20^th day of gestation female sacrified; morphological, visceral, skeletal, biochemical and histopathological studies were carried out to evaluate its harmful effect. Meloxicam increased abortion rate and fetal resorptions as well as growth retardation and external malformations as hematoma and paralysis of limbs. Visceral examination showed defects in internal organs. Weak and incomplete ossification in axial and appendicular system were observed by skeletal examination. Drug caused increased level of MDA meanwhile reduction of glutathione reduced in liver tissue of fetuses. The histopathological examination revealed presence of marked degenerative changes in liver and kidney of fetuses. This study support and proof the potential risks of the Meloxicam administration on fetuses.

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