Adverse Effects of Repaglinide Alone and in Combination of Vitamin E

Document Type : Original Article


Department of Pharmacology , Faculty of veterinary Medicine ,Zagazig university, Egypt


The purpose of this study is to investigate  the adverse effects of repaglinide. Twenty  of  male  albino  rats  were  randomly  divided   into  four groups (five of each): (i) Control, (ii) Vitamin E (100 mg/kg b.wt) administered orally, (iii) Repaglinide (0.09mg/kg b.wt) administered orally, and  (iv)  Vitamin E plus repaglinide were administered orally at the same doses. Treatment with Vitamin E and /or repaglinide were continued for 2 successive weeks. At the end of experiment, serum samples were obtained for some biochemical analysis including:  catalase (CAT), superoxidase dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA). Kidney and liver were taken for histopathological examination. The obtained results showed a significant decrease in the serum level of CAT, SOD, GPx and a significant increase in the level of MDA in repaglinide group compared to the control group. Meanwhile, the group treated with vitamin E plus repaglinide revealed an improvement in the values of antioxidant enzymes compared to rats administered repaglinide group. Liver sections showed a focal co-agulative necrosis with cell aggregation  and kidney sections revealed a necrotic glomeruli with destructed  hemorrhagic renal tubules in the rats treated with repaglinide. However, rats treated with both vitamin E plus repaglinide illustrated a noticed recovery of liver and kidney tissues. In conclusion, administration of vitamin E can be recommended to overcome side effects associated with repaglinide by its protective antioxidant activity.


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