Prospective Ameliorative Activity of Neem (Azadirachta Indica) on Iron Oxide Nanoparticle-Induced Multiple Organ Injury via Attenuating TNF-α Pathway

Document Type : Original Article

Authors

1 Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Egypt. Menoufia University Hospital, Faculty of Veterinary Medicine, Sadat City University, Egypt.

2 Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Egypt.

3 Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Egypt.

Abstract

Neem trees (Azadirachta indica) have received a lot of academic interest recently because of their strong antioxidant and anti-proliferative capabilities. In this study, we evaluated the potential alleviating effect of neem on Fe2O3 NP -induced damage in brain, heart, and testis. Twenty-eight male albino rats were divided into four equal groups at random. The control group was given D.W orally for 45 days, Neem group was given 200 mg/kg/day orally for 45 days, Fe2O3 NP group was given 60 mg/kg of Fe2O3 NP I/P at the 31th-45th day, Fe2O3 NP +Neem group was given 200 mg/kg day of neem orally for 45 days + 60 mg/kg of Fe2O3 NP IP at the 31th–45th day. In the present investigation, histopathological examination of brain, heart, and testis sections revealed cellular degeneration and necrosis after Fe2O3 NP exposure. Also, TNF-α expressions were considerably elevated. Neem pr-treatment maintain tissue architecture in Fe2O3 NP-intoxicated rats. Our findings proved that neem have a potential protective impact against cellular damage induced by Fe2O3 NP through its anti-inflammatory, antiapoptotic, and antioxidant effects.

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